반응 #58748

반응 방정식

5-Bromo-pyridine-3-carbaldehyde

NaB(OAc)3H

piperidine

→

product

수율 71.0%

3-Bromo-5-piperidin-1-yimethyl-pyridine

수율 71.0%

용매

DCM

반응 조건

후처리

1. 1
   기타The reaction was quenched by the addition of 1 M NaOH solution (5 mL)
2. 2
   workup.STIRRINGthe mixture was stirred for 1 h
3. 3
   추출The reaction mixture was extracted with DCM (3×15 mL)
4. 4
   건조dried over Na2SO4
5. 5
   여과filtered
6. 6
   농축concentrated

실험 절차

5-Bromo-pyridine-3-carbaldehyde (0.190g, 1 mmol), NaB(OAc)3H (0.320 g, 1.50 mmol) and piperidine (0.090 g, 1.05 mmol) were suspended in DCM (8 mL) and the reaction mixture was stirred overnight at rt. The reaction was quenched by the addition of 1 M NaOH solution (5 mL) and the mixture was stirred for 1 h. The reaction mixture was extracted with DCM (3×15 mL). The organic extracts were combined, dried over Na2SO4, filtered, and concentrated to yield a crude oily product (0.18 g, 71%). This crude product was carried to the next step.

출처