반응 #58740

반응 방정식

NaH

3-piperidin-1-yl-propan-1-ol

2-bromo-5-piperidin-1-ylmethyl-pyridine

→

title compound

5-Piperidin-1-ylmethyl-2-(3-piperidin-1-yl-propoxy)-pyridine

용매

DMF

반응 조건

후처리

1. 1
   workup.WAITAfter 18 h
2. 2
   추출the reaction is extracted with ethyl acetate (100 mL)
3. 3
   세척washed with 1 N NaHCO3 (50 mL) and H2O(3×50 mL)
4. 4
   기타The organic layer is dried
5. 5
   농축concentrated
6. 6
   기타chromatographed on SiO2

실험 절차

To a suspension of NaH (1.5 mmol) in DMF is added 3-piperidin-1-yl-propan-1-ol (1.1 mmol). After 30 min, 2-bromo-5-piperidin-1-ylmethyl-pyridine (1 mmol) is added to the mixture. After 18 h, the reaction is extracted with ethyl acetate (100 mL) and washed with 1 N NaHCO3 (50 mL) and H2O(3×50 mL). The organic layer is dried, concentrated, and chromatographed on SiO2 to provide the title compound.

출처