반응 #586501

반응 방정식

Methyl thiosalicylate

2-(hexylamino)isonicotinonitrile

triethylamine

→

titled compound

수율 18.1%

2-[2-(Hexylamino)-4-pyridyl]-4H-1,3-benzothiazine-4-one

수율 18.1%

용매

toluene

반응 조건

후처리

1. 1
   온도The reaction mixture was refluxed for 14 hrs
2. 2
   세척eluted with hexane-ethyl acetate (2:1
3. 3
   기타v/v) and recrystallized from ethanol

실험 절차

Methyl thiosalicylate (0.44 g, 2.6 mmol) and 2-(hexylamino)isonicotinonitrile (0.26 g, 1.3 mmol) were dissolved in toluene (2.0 ml), and triethylamine (0.40 ml, 2.9 mmol) was added thereto. The reaction mixture was refluxed for 14 hrs, subjected to a silica gel (50 g) chromatography, eluted with hexane-ethyl acetate (2:1, v/v) and recrystallized from ethanol to give the titled compound (0.08 g, 18%) as white crystals.

출처