반응 #58622

반응 방정식

2-amino-thiophene-3-carboxylic acid methyl ester

trichloroacetyl isocyanate

→

desired product

Methyl 2-({[(trichloroacetyl)amino]carbonyl}amino)thiophene-3-carboxylate

용매

THF

반응 조건

후처리

1. 1
   workup.ADDITIONAfter the addition
2. 2
   기타a precipitate formed

실험 절차

To a stirred solution of 2-amino-thiophene-3-carboxylic acid methyl ester (1 eq) in anhydrous THF (mL) was added trichloroacetyl isocyanate (1 eq) slowly over a period of 5 min. After the addition was complete, a precipitate formed and the reaction stirred for an additional 1 h. The desired product was obtained by filtration to give methyl 2-({[(trichloroacetyl)amino]carbonyl}amino)thiophene-3-carboxylate (99%) as an off-white solid. The product was used in the next step without any further purification. LC/MS (ES, M+H=345).

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