반응 #586136

반응 방정식

sodium bicarbonate

[3-(2,4-dichlorophenyl)phenyl] isopropyl sulfide

m-chloroperbenzoic acid

→

[3-(2,4-dichlorophenyl)phenyl] isopropyl sulfoxide

수율 85.0%

용매

chloroform

반응 조건

후처리

1. 1
   workup.STIRRINGthe reaction mixture was stirred for 2 hours
2. 2
   workup.STIRRINGThe reaction mixture was stirred at room temperature for another 12 hours
3. 3
   세척The chloroform layer was washed with 5% aqueous sodium sulfite and water
4. 4
   건조dried over anhydrous magnesium sulfate
5. 5
   workup.DISTILLATIONthe solvent was distilled off under reduced pressure
6. 6
   기타Purification of the residue by silica gel column chromatography

실험 절차

To 1.0 g (3.4 mmol) of [3-(2,4-dichlorophenyl)phenyl] isopropyl sulfide in 50 ml of chloroform, 0.7 g (4.1 mmol) of m-chloroperbenzoic acid was added at 0° C. with stirring, and the reaction mixture was stirred for 2 hours. The reaction mixture was stirred at room temperature for another 12 hours, and 5% aqueous sodium bicarbonate was added for separation. The chloroform layer was washed with 5% aqueous sodium sulfite and water and dried over anhydrous magnesium sulfate, and the solvent was distilled off under reduced pressure. Purification of the residue by silica gel column chromatography afforded 0.9 g of [3-(2,4-dichlorophenyl)phenyl] isopropyl sulfoxide (yield 85.0%) as a colorless dough (nD20 1.6169).

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