반응 #586133

반응 방정식

4-(5-chlorothiophen-2-yl)-2-fluorobenzonitrile

S-cyclopropylmethylisothiourea hydrobromide

→

4-(5-chlorothiophen-2-yl)-2-cyclopropylmethylthiobenzonitrile

수율 91.0%

반응 조건

후처리

1. 1
   기타to react in the same manner

실험 절차

0.9 g (4.0 mmol) of 4-(5-chlorothiophen-2-yl)-2-fluorobenzonitrile and 0.9 g (4.3 mmol) of S-cyclopropylmethylisothiourea hydrobromide were allowed to react in the same manner as described above in Example 8 (4), and purification of the crude product by silica gel column chromatography afforded 1.1 g of 4-(5-chlorothiophen-2-yl)-2-cyclopropylmethylthiobenzonitrile (yield 91%) as yellow feathery crystals (m.p. 123-124° C.).

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