반응 #586113

반응 방정식

N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide

→

N-{(S)-1-hydroxy-3-phenyl-2-propyl }-2,5-dihydroxybenzamide

수율 85.0%

용매

methanol

반응 조건

후처리

1. 1
   기타In a flask equipped with a magnetic stirring bar
2. 2
   기타Nitrogen is bubbled through the solution and 10% Pd on charcoal
3. 3
   workup.ADDITIONis added
4. 4
   기타After flushing with nitrogen
5. 5
   기타The suspension is flushed with nitrogen
6. 6
   여과filtered
7. 7
   세척rinsed over Celite
8. 8
   농축The filtrate is concentrated under vacuum

실험 절차

In a flask equipped with a magnetic stirring bar and a rubber septum is dissolved the N-{(S)-1-hydroxy-3-phenyl-2-propyl}-5-benzyloxy-2-hydroxybenzamide in methanol. Nitrogen is bubbled through the solution and 10% Pd on charcoal is added. After flushing with nitrogen, the suspension is placed under hydrogen atmosphere and stirred for 2 hours. The suspension is flushed with nitrogen and filtered and rinsed over Celite. The filtrate is concentrated under vacuum. In this fashion is obtained N-{(S)-1-hydroxy-3-phenyl-2-propyl }-2,5-dihydroxybenzamide (85%).

출처