반응 #586102

반응 방정식

N-(2-methyl-3-(1,1-dimethylpropyl)phenyl)form-amide

potassium hydroxide

methanol

→

3-(1,1-dimethypropyl)-2-methyl-phenylamine

용매

water

반응 조건

후처리

1. 1
   온도at reflux temperature for 15 hours
2. 2
   workup.ADDITIONis added
3. 3
   추출the reaction mixture is extracted with ethylacetate
4. 4
   건조After drying of the organic phase over sodium sulfate and evaporation of the solvent in a water jet vacuum
5. 5
   기타the product is purified by destillation (bp. ca. 70° C., 13,33 Pa)

실험 절차

2,21 g (10.77 mmol) N-(2-methyl-3-(1,1-dimethylpropyl)phenyl)form-amide, 1,42 g (21.54 mmol) 85% potassium hydroxide and 9 ml methanol are heated under stirring at reflux temperature for 15 hours. After cooling 100 ml of water is added and the reaction mixture is extracted with ethylacetate. After drying of the organic phase over sodium sulfate and evaporation of the solvent in a water jet vacuum, the product is purified by destillation (bp. ca. 70° C., 13,33 Pa). This gives 1.7 g of 2-Methyl-3-(1,1-dimethylpropyl)phenylamine in the form of a colourless oil (89% of theory).

출처