반응 #586100

반응 방정식

product

2-(2-Nitrophenyl)-3-(trimethylsilyl)-2-propene

hydrogen

→

2-(2-aminophenyl)-3-(trimethylsilyl)-propane

수율 88.0%

용매

tetrahydrofurane

반응 조건

후처리

1. 1
   여과The catalyst was filtered off
2. 2
   기타after evaporation of the solvent
3. 3
   기타the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane)

실험 절차

The reaction product of step A [7.2 g] was hydrogenated in tetrahydrofurane over palladium on charcoal at atmospheric pressure and room temperature until the uptake of hydrogen ceased. The catalyst was filtered off and, after evaporation of the solvent, the product was chromatographed on silacagel (eluent: 10% ethylacetate in hexane) to yield 2-(2-aminophenyl)-3-(trimethylsilyl)-propane [4.7 g; 88% purity according to NMR]. This product was used in the next step without further purification.

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