반응 #58524

반응 방정식

product

1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid tert-butyl ester

trifluoroacetic acid

→

1-Benzyl-4-(4,5-dibromo-thiophen-2-yl)-pyrrolidine-3-carboxylic acid trifluoroacetate

용매

CH2Cl2

반응 조건

후처리

1. 1
   기타Next, the solvent was evaporated
2. 2
   workup.ADDITIONtoluene (50 ml) was added
3. 3
   기타subsequently evaporated in vacuo at 40° C.
4. 4
   기타to remove residual TFA
5. 5
   기타The crude subtitle product was used without further purification

실험 절차

The product of step b) (2.6 g, 5.2 mmol) in CH2Cl2 (25 ml) and trifluoroacetic acid (TFA) (75 ml) was stirred at 220C for 16 hours. Next, the solvent was evaporated and toluene (50 ml) was added and subsequently evaporated in vacuo at 40° C. to remove residual TFA. The crude subtitle product was used without further purification.

출처