반응 #58481

반응 방정식

hydrochloric acid

2-chloropyridinoyl-piperidine

benzophenone imine

2,2′-bis(diphenylphosphino)-1,1′-binaphthyl

sodium t-butoxide

→

2-aminopyridinoyl-piperidine

용매

tetrahydrofuran

toluene

반응 조건

후처리

1. 1
   기타purified

실험 절차

Next, the 2-chloropyridinoyl-piperidine intermediate is reacted with benzophenone imine in the presence of tris(dibenzylidineacetone)-dipalladium(0) Pd2(dba)3) as a catalyst, and 2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (BINAP) and sodium t-butoxide in a suitable solvent, such as toluene, at reflux, to substitute the halo group with the benzophenone imino group. After work-up, this intermediate is typically reacted with hydrochloric acid in a suitable solvent, such as tetrahydrofuran, and then purified to give the corresponding 2-aminopyridinoyl-piperidine intermediate.

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