반응 #58469

ord-780706090e054081a3d2c3a00d549a13

반응 방정식

O=C(O)C[C@@H]1CCCN1C(=O)OCc1ccccc1
(S)-2-carboxymethyl-pyrrolidine-1-carboxylic acid benzyl ester
O=C(CBr)c1ccccc1
2-bromoacetophenone
O=C(C[C@@H]1CCCN1C(=O)OCc1ccccc1)OCC(=O)c1ccccc1
title compound
수율 48.3%
O=C(C[C@@H]1CCCN1C(=O)OCc1ccccc1)OCC(=O)c1ccccc1
(S)-2-(2-Oxo-2-phenyl-ethoxycarbonylmethyl)-pyrrolidine-1-carboxylic acid benzyl ester
수율 48.3%

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

The title compound (0.700 g) was prepared from (S)-2-carboxymethyl-pyrrolidine-1-carboxylic acid benzyl ester (1.00 g, Aoyama et al, Chem. Pharm. Bull., 3249, 29,11,1981) and 2-bromoacetophenone (0.760 g) according to the method of description 36.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07423052B2uspto-grants-2008_09