반응 #58351

반응 방정식

(±)-cis-6-(3,4-dimethoxyphenyl)-cyclohex-3-enylamine

3,4-bis-cyclopropylmethoxybenzoyl chloride

→

title compound

수율 93.5%

(±)-cis-3,4-Bis-cyclopropylmethoxy-N-[6-(3,4-dimethoxyphenyl)cyclohex-3-enyl]benzamide

수율 93.5%

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   추출After 1 h the reaction mixture is extracted with 2 N hydrochloric acid and water
2. 2
   기타the organic phase is dried
3. 3
   농축concentrated

실험 절차

20 g of (±)-cis-6-(3,4-dimethoxyphenyl)-cyclohex-3-enylamine (compound G1) are dissolved in 125 ml of dichloromethane and treated with a solution of 24.1 g of 3,4-bis-cyclopropylmethoxybenzoyl chloride in 125 ml of dichloromethane at room temperature. After 1 h the reaction mixture is extracted with 2 N hydrochloric acid and water, the organic phase is dried using sodium sulfate and concentrated. 38.3 g of the title compound of m.p. 152-153.5° C. are obtained.

출처