반응 #583489
ord-7294be9dc7a1496da96bccbb1c3cfef8
반응 조건
온도
0°CELSIUS
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출The reaction mixture was extracted with 3×2 ml of dichloromethane
- 2건조The combined organic layer was dried over anhydrous NaSO4
- 3농축concentrated under vacuum
실험 절차
To a solution of PG490 (triptolide, 17.3 mg, 0.048 mmol) in dichloromethane (1.0 ml) at 0° C. was added (diethylamino)sulfur trifluoride (DAST, 100 μl, 0.763 mmol) under N2. The reaction mixture was stirred at 0° C. for 2 hrs, and saturated NaHCO3 solution (0.8 ml) was then added. The reaction mixture was extracted with 3×2 ml of dichloromethane. The combined organic layer was dried over anhydrous NaSO4 and concentrated under vacuum. The desired product (PG763) was obtained in quantitative yield.