반응 #582637

반응 방정식

2-(2-Methoxy-5-nitrophenyl)acetic acid

2-(2-methoxy-5-nitrophenyl)acetic acid

EDC

Et3N

dimethylamine hydrochloride

→

2-(2-methoxy-5-nitrophenyl)-N,N-dimethyl-acetamide

용매

CH2Cl2

CH2Cl2

반응 조건

후처리

1. 1
   세척the mixture was washed twice with 1M HCl, twice with 1M NaOH, water and brine
2. 2
   기타Removal of the solvent under reduced pressure

실험 절차

2-(2-Methoxy-5-nitrophenyl)acetic acid (17.1 g, 1 eq, Step B), EDC (18.6 g, 1.2 eq.), Et3N (9.8 g, 13.6 mL, 1.2 eq) and dimethylamine hydrochloride (7.9 g, 1.2 eq.) in 150 mL of CH2Cl2 were stirred together with exclusion of air overnight. CH2Cl2 (150 mL) was added and the mixture was washed twice with 1M HCl, twice with 1M NaOH, water and brine. Removal of the solvent under reduced pressure followed by silica gel chromatography (90:10 CH2Cl2:EtOAc) afforded pure 2-(2-methoxy-5-nitrophenyl)-N,N-dimethyl-acetamide as a white solid.

출처