반응 #58206

반응 방정식

N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]acetamide

hydrochloric acid

sodium hydroxide

→

oily product

수율 94.0%

N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]amine

수율 94.0%

반응 조건

후처리

1. 1
   온도The mixture is refluxed for 4 hours
2. 2
   온도cooled in an ice bath
3. 3
   추출extracted three times with ethyl acetate
4. 4
   세척The combined extracts are washed with water and with brine
5. 5
   건조dried over anhydrous sodium sulfate
6. 6
   기타evaporated under reduced pressure

실험 절차

4 g (12.9 mmol) of N-[8-(naphthalen-2-ylmethyl)-8-azabicyclo[3.2.1]oct-3-yl]acetamide are poured into 13 mL of 5N hydrochloric acid. The mixture is refluxed for 4 hours and then cooled in an ice bath, basified with 35% sodium hydroxide and extracted three times with ethyl acetate. The combined extracts are washed with water and with brine, dried over anhydrous sodium sulfate and then evaporated under reduced pressure. 3.2 g of oily product are obtained (94% yield).

출처