반응 #581289

반응 방정식

4-amino-2-(4-fluorobenzyl)-10-(benzyloxy)-8-methyl-7,8-dihydropyrazino[1′,2′:1,5]-pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

boron tribromide

→

titled compound

4-Amino-2-(4-Fluorobenzyl)-10-hydroxy-8-methyl-7,8-dihydropyrazino-[1′,2′:1,5]-pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione

용매

dichloromethane

dichloromethane

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated under vacuum
2. 2
   기타the residue subjected to purification on reverse phase HPLC
3. 3
   기타Collection and lyophilization of appropriate fractions

실험 절차

To a solution of 4-amino-2-(4-fluorobenzyl)-10-(benzyloxy)-8-methyl-7,8-dihydropyrazino[1′,2′:1,5]-pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-dione (0.11 g, 0.25 mmol) in dichloromethane (10 mL) at 0° C., a solution of boron tribromide in dichloromethane (0.7 mL, 1M) was added. The resultant solution was stirred at room temperature overnight. The reaction mixture was concentrated under vacuum and the residue subjected to purification on reverse phase HPLC. Collection and lyophilization of appropriate fractions provided the titled compound.

출처