반응 #58090

ord-6ce67abe01174be09ba2b5676c9ac2f4

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타The sodium chloride precipitated
  2. 2
    여과filtered
  3. 3
    온도cooled
  4. 4
    기타The precipitate formed
  5. 5
    기타is separated off
  6. 6
    세척washed with ethanol and diethyl ether

실험 절차

4.6 g (0.20 mol) sodium in 200 mL ethanol are combined at ambient temperature with a solution of 25 g (0.20 mol) ethyl acetimidate hydrochloride in 200 mL ethanol. The sodium chloride precipitated is suction filtered and 33.2 g (0.20 mol) 4-methoxybenzoic acid hydrazide are added to the filtrate. The reaction mixture is stirred overnight at ambient temperature and then cooled. The precipitate formed is separated off and washed with ethanol and diethyl ether. Yield: 33.6 g (81%); melting range=179-181° C.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07423036B2uspto-grants-2008_09