반응 #580575

반응 방정식

6-o-tolylnicotinaldehyde

sodium borohydride

→

product

수율 100.0%

(6-o-Tolylpyridin-3-yl)methanol

수율 100.0%

용매

ethanol

반응 조건

후처리

1. 1
   기타the reaction mixture was quenched with saturated sodium bicarbonate solution and, after 30 min
2. 2
   기타partitioned between dichloromethane and brine
3. 3
   추출The organic extract
4. 4
   건조was dried over magnesium sulfate
5. 5
   농축concentrated

실험 절차

To a solution of 1.070 g (5.43 mmol) of 6-o-tolylnicotinaldehyde in 19 mL of ethanol at 0-5° C., was added 287 mg(7.5 mmol, 1.4 eq.) of sodium borohydride. After 2 h, the reaction mixture was quenched with saturated sodium bicarbonate solution and, after 30 min, partitioned between dichloromethane and brine. The organic extract was dried over magnesium sulfate and concentrated to give the indicated product as a colorless oil, 1.08 g, 100% yield.

출처