반응 #58039

반응 방정식

trans-[4-(benzylimino-methyl)-cyclohexyl]-carbamic acid tert-butyl ester

oxalic acid

→

trans-(4-Formyl-cyclohexyl)-carbamic acid tert-butyl ester

수율 80.0%

용매

water THF

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated under reduced pressure and methylene chloride (50 mL)
2. 2
   workup.ADDITIONwas added to the residue
3. 3
   기타The organic phase was dried
4. 4
   농축concentrated under reduced pressure

실험 절차

A solution of trans-[4-(benzylimino-methyl)-cyclohexyl]-carbamic acid tert-butyl ester (2.50 g, 8.00 mmol) and oxalic acid (0.80 g) in water/THF (50 mL, 1:1) was stirred for 10 h at room temperature. The reaction mixture was concentrated under reduced pressure and methylene chloride (50 mL) was added to the residue. The organic phase was dried and concentrated under reduced pressure to give trans-(4-Formyl-cyclohexyl)-carbamic acid tert-butyl ester (1.3 g, 80%).

출처