반응 #57999

반응 방정식

tert-butylamine

(chloromethyl)trimethylsilane

NaOH

→

title compound 77

N-tert-butyl-N-(trimethylsilylmethyl)amine

반응 조건

후처리

1. 1
   온도After cooling to ambient temperature
2. 2
   추출extracted three times with diethyl ether
3. 3
   세척The combined organic extracts were washed with brine
4. 4
   건조dried (MgSO4)
5. 5
   기타the volatiles evaporated in vacuo
6. 6
   workup.DISTILLATIONDistillation (atmospheric pressure; ˜135° C.) of the residual liquid

실험 절차

A mixture of tert-butylamine (18.0 mL, 171 mmol) and (chloromethyl)trimethylsilane (7.00 g, 57.1 mmol) was heated in a thick-walled glass tube at 200° C. overnight. After cooling to ambient temperature, the reaction mixture was poured into 1 N NaOH and extracted three times with diethyl ether. The combined organic extracts were washed with brine, dried (MgSO4), and the volatiles evaporated in vacuo. Distillation (atmospheric pressure; ˜135° C.) of the residual liquid gave the title compound 77 as a colorless liquid.

출처