반응 #579257

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sarcosine

(2,5-dioxoazolidinyloxycarbonyloxy)ethyl benzoate

→

title compound ( 40 )

수율 44.4%

2-[N-Methyl(phenylcarbonyloxyethoxy)carbonylamino]acetic Acid

수율 44.4%

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후처리

1. 1
   기타were reacted

실험 절차

Following the general procedure for the synthesis of acyloxyalkyl carbamates, sarcosine (0.104 g, 1.17 mmol) and (2,5-dioxoazolidinyloxycarbonyloxy)ethyl benzoate (0.3 g, 0.976 mmol) were reacted to provide 122 mg (44% yield) of the title compound (40) as a colorless semi-solid after work-up and mass-guided preparative HPLC purification. 1H NMR (CD3OD, 400 MHz): δ=8.01 (d, 2H), 7.61 (t, 1H), 7.44 (t, 2H), 7.01 (q, 1H), 4.12 (m, 2H), 3.01 (2s, 3H), 1.62-1.58 (dd, 3H). MS (ESI) m/z 304.05 (M+Na)+; 280.11 (M−H)−.

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