반응 #579256

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sarcosine

(2,5-dioxoazolidinyloxycarbonyloxy)ethyl 2-methylbenzoate

→

title compound ( 39 )

수율 53.3%

2-{N-Methyl[(2-methylphenylcarbonyloxy)ethoxy]carbonylamino}acetic Acid

수율 53.3%

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후처리

1. 1
   기타were reacted

실험 절차

Following the general procedure for the synthesis of acyloxyalkyl carbamates, sarcosine (0.2 g, 2.24 mmol) and (2,5-dioxoazolidinyloxycarbonyloxy)ethyl 2-methylbenzoate (0.6 g, 1.86 mmol) were reacted to provide 0.293 g (53.1% yield) of the title compound (39) as a white wax after work-up and mass-guided preparative HPLC purification. 1H NMR (CD3OD, 400 MHz): δ=7.81 (d, 1H), 7.40 (t, 1H), 7.22 (d, 2H), 7.01 (q, 1H), 4.1 (m, 2H), 3.0 (2s, 3H), 2.58 (s, 3H), 1.61-1.59 (2d, 3H). MS (ESI) m/z 318.07 (M+Na)+, 294.10 (M−H)−.

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