반응 #579248

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D-serine

(2,5-dioxoazolidinyloxycarbonyloxy)ethyl 2-methylpropanoate

→

title compound ( 29 )

수율 40.3%

(2R)-3-Hydroxy-2-{[(2-methylpropanoyloxy)ethoxy]carbonylamino}propanoic Acid

수율 40.3%

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후처리

1. 1
   기타were reacted

실험 절차

Following the general procedure for the synthesis of acyloxyalkyl carbamates, D-serine (252 mg, 2.4 mmol) and (2,5-dioxoazolidinyloxycarbonyloxy)ethyl 2-methylpropanoate (546 mg, 2.0 mmol) were reacted to provide 212 mg (40% yield) of the title compound (29) as a white powder after work-up and mass-guided preparative HPLC purification. 1H NMR (CDCl3, 400 MHz): δ=6.79 (m, 1H), 6.03 (t, 0.2H), 5.58 (br s, 1H), 4.41 (m, 1H), 4.05 (m, 1H), 3.94 (m, 1H), 2.57 (m, 1H), 1.48 (2d, 3H), 1.19 (2d, 6H). MS (ESI) m/z 281.11 (M+NH4)+; 286.11 (M+Na)+; 262.12 (M−H)−.

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