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ACPC

(2,5-dioxoazolidinyloxycarbonyloxy)ethyl benzoate

→

title compound ( 4 )

수율 38.5%

1-[(Phenylcarbonyloxyethoxy)carbonylamino]cyclopropanecarboxylic Acid

수율 38.5%

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후처리

1. 1
   기타were reacted

실험 절차

Following the general procedure for the synthesis of acyloxyalkyl carbamates, ACPC (121 mg, 1.1 mmol) and (2,5-dioxoazolidinyloxycarbonyloxy)ethyl benzoate (341 mg, 1.0 mmol) were reacted to provide 113 mg (35% yield) of the title compound (4) as a white powder after work-up and mass-guided preparative HPLC purification. M.p.: 173.8-175.8° C. 1H NMR (CD3CN, 400 MHz): δ=8.00 (d, 2H), 7.61 (t, 1H), 7.50 (t, 2H), 6.99 (q, 1H), 6.31 (s, 0.8H), 6.01 (br s, 0.2H), 1.60 (d, 3H), 1.42 (m, 2H), 1.09 (m, 2H). MS (ESI) m/z 294.10 (M+H)+; 311.12 (M+NH4)+; 316.11 (M+Na)+; 292.12 (M−H)−.

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