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ACPC

(2,5-dioxoazolidinyloxycarbonyloxy)ethyl 2-methylbenzoate

→

title compound ( 3 )

수율 43.3%

1-{[(2-Methylphenylcarbonyloxy)ethoxy]carbonylamino}cyclopropanecarboxylic Acid

수율 43.3%

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후처리

1. 1
   기타were reacted

실험 절차

Following the general procedure for the synthesis of acyloxyalkyl carbamates, ACPC (121 mg, 1.2 mmol) and (2,5-dioxoazolidinyloxycarbonyloxy)ethyl 2-methylbenzoate (321 mg, 1.0 mmol) were reacted to provide 133 mg (43% yield) of the title compound (3) as a white powder after work-up and mass-guided preparative HPLC purification. 1H NMR (CDCl3, 400 MHz): δ=7.85 (d, 1H), 7.40 (t, 1H), 7.21 (t, 2H), 7.01 (q, 1H), 5.79 (br s, 0.3H), 5.41 (s, 0.7H), 2.58 (s, 3H), 1.60 (m, 5H), 1.30 (m, 2H). MS (ESI) m/z 325.17 (M+NH4)+; 330.12 (M+Na)+; 306.15 (M−H)−.

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