반응 #577969

반응 방정식

water

hydrogen peroxide

2-(3,4-dichloro-benzylidene)-indane-1,3-dione

sodium hydroxide

→

3-(3,4-dichlorophenyl)-spiro (oxirane-2,2′-indan)-1′,3′-dione

수율 95.0%

용매

MeOH

반응 조건

후처리

1. 1
   workup.ADDITIONAfter addition
2. 2
   여과the resulting solid was collected by filtration
3. 3
   세척washed with water and MeOH

실험 절차

To a suspension of 2-(3,4-dichloro-benzylidene)-indane-1,3-dione (1c) (1.6 g, 5.2 mmol) in MeOH (13 mL) was added hydrogen peroxide (30% solution, 3 mL). The mixture was cooled to 0° C. and sodium hydroxide (1N 300 μL) was added dropwise. After addition was completed, stirring was continued at room temperature for 1 h. The mixture was then poured into water (5 mL) and the resulting solid was collected by filtration and washed with water and MeOH. After drying under high vacuum 3-(3,4-dichlorophenyl)-spiro (oxirane-2,2′-indan)-1′,3′-dione (1d) (1.6 g, 95% yield) was obtained.

출처