반응 #577213

반응 방정식

4-cyano-4′-hydroxybiphenyl

bromide

potassium carbonate

butanone

→

4-allyloxy-4′-cyanobiphenyl

용매

Water

반응 조건

후처리

1. 1
   기타A reaction mixture obtained
2. 2
   온도was refluxed for 7 hours
3. 3
   기타was then separated
4. 4
   세척An organic layer was washed with water
5. 5
   건조dried over anhydrous magnesium sulfate
6. 6
   workup.DISTILLATIONThe solvent was distilled off
7. 7
   기타to obtain a residue, which
8. 8
   기타was purified by silica gel column chromatography
9. 9
   기타subjected to recrystallization from ethanol

실험 절차

A reaction mixture obtained by adding 20 g of 4-cyano-4′-hydroxybiphenyl, 20 g of ally bromide and 25 g of potassium carbonate to 250 mL of butanone was refluxed for 7 hours. Water was added to the reaction mixture, which was then separated. An organic layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was distilled off to obtain a residue, which was purified by silica gel column chromatography using toluene as an elusion solvent and then subjected to recrystallization from ethanol to obtain 22 g of 4-allyloxy-4′-cyanobiphenyl.

출처