반응 #57667

반응 방정식

5,7-dichloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

iodomethane

K2CO3

→

5,7-dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester

수율 99.3%

용매

DMF

반응 조건

후처리

1. 1
   세척The mixture was washed with brine
2. 2
   추출extracted with ethyl acetate
3. 3
   세척The combined ethyl acetate solution was washed with brine
4. 4
   기타Removal of the solvent in vacuo

실험 절차

To 120 mg of 5,7-dichloro-4-hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester was added 1 mL of iodomethane, 200 mg of K2CO3 and 4 mL of DMF. The mixture was stirred at room temperature overnight. The mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate solution was washed with brine. Removal of the solvent in vacuo gave 125 mg (99% yield) of 5,7-dichloro-4-methoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester as off-white solid.

출처