반응 #57634

반응 방정식

3-Methyl-4-trifluoromethanesulfonyloxy-benzofuran-2-carboxylic acid tert-butyl ester

K2CO3

phenylboronic acid

1,2-dimethoxyethane

→

3-methyl-4-phenyl-benzofuran-2-carboxylic acid tert-butyl ester

수율 77.0%

용매

water

반응 조건

후처리

1. 1
   온도The mixture was heated
2. 2
   추출was extracted with ethyl acetate
3. 3
   추출The organic extract
4. 4
   세척was washed with water
5. 5
   건조dried over sodium sulfate
6. 6
   여과Filtration
7. 7
   기타followed by removal of the solvent in vacuo
8. 8
   기타gave the crude product (71 mg), which
9. 9
   기타was purified by column chromatography

실험 절차

3-Methyl-4-trifluoromethanesulfonyloxy-benzofuran-2-carboxylic acid tert-butyl ester (85 mg, 0.25 mmol) was mixed with K2CO3 (68 mg, 0.5 mmol), phenylboronic acid (31 mg, 0.25 mmol), Pd(Ph3)4 (14 mg, 0.01 mmol), 1 mL of 1,2-dimethoxyethane and 2 drops of water. The mixture was heated and stirred in an 85° C. oil bath for 2 h. The reaction mixture was poured into water and was extracted with ethyl acetate. The organic extract was washed with water and dried over sodium sulfate. Filtration followed by removal of the solvent in vacuo gave the crude product (71 mg), which was purified by column chromatography to give 53 mg (77% yield) of 3-methyl-4-phenyl-benzofuran-2-carboxylic acid tert-butyl ester, obtained as white solid.

출처