반응 #57616

반응 방정식

4-hydroxy-2-benzofurancarboxylic acid methyl ester

2-bromopropane

potassium carbonate

→

methyl 4-isopropoxy-1-benzofuran-2-carboxylate

수율 100.0%

용매

DMF

반응 조건

후처리

1. 1
   농축The reaction mixture was concentrated in vacuo
2. 2
   추출the residue was extracted with ethyl acetate
3. 3
   세척The organic layer washed with water and brine
4. 4
   건조dried over sodium sulfate
5. 5
   여과filtered
6. 6
   농축concentrated in vacuo

실험 절차

To a solution of 0.41 g (2.13 mmol) of 4-hydroxy-2-benzofurancarboxylic acid methyl ester in 7 mL of DMF was added 0.80 mL (8.54 mmol) of 2-bromopropane and 1.18 g (8.54 mmol) of potassium carbonate. The reaction was stirred at room temperature overnight. The reaction mixture was concentrated in vacuo, and the residue was extracted with ethyl acetate. The organic layer washed with water and brine, dried over sodium sulfate, filtered, and concentrated in vacuo to provide 0.49 g of methyl 4-isopropoxy-1-benzofuran-2-carboxylate. Yield ˜100%; m.p. 43-45° C.; MS: 235.1 (M+H)+.

출처