반응 #57601

반응 방정식

3-methyl-4-hydroxy-5-ethylbenzofuran carboxylic acid ethyl ester

ethyl 3-methyl-4-hydroxy-5-ethylbenzofuran-2-carboxylate

2-bromopropane

→

5-ethyl-4-isopropoxy-3-methylbenzofuran-2-carboxylic acid ethyl ester

수율 89.7%

반응 조건

실험 절차

According to the procedure of Example 86, Step 3 0.200 g (0.81 mmol) of 3-methyl-4-hydroxy-5-ethylbenzofuran carboxylic acid ethyl ester (Example 86, Step 2) and 0.379 mL (4.03 mmol) of 2-bromopropane gave 0.211 g of 5-ethyl-4-isopropoxy-3-methylbenzofuran-2-carboxylic acid ethyl ester after chromatography on silica gel eluting with ethyl acetate/hexanes (1:20).

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