반응 #57549

반응 방정식

3-bromobenzonitrile

sulfur

ethylenediamine

→

2-(3-bromo-phenyl)-4,5-dihydro-1H-imidazole

반응 조건

후처리

1. 1
   온도The mixture was refluxed overnight
2. 2
   workup.ADDITIONthen poured onto ice water, which
3. 3
   기타to precipitate as a white solid
4. 4
   기타The product was isolated by vacuum filtration
5. 5
   기타dried in a vacuum oven (545 mg, 88%)

실험 절차

To a solution of 3-bromobenzonitrile (500 mg, 2.75 mmol) in ethylenediamine (3.5 mL) was added sulfur (44 mg, 1.4 mmol). The mixture was refluxed overnight then poured onto ice water, which caused the product to precipitate as a white solid. The product was isolated by vacuum filtration and dried in a vacuum oven (545 mg, 88%). 1H-NMR (CDCl3) δ 7.93 (t, J=1.7 Hz, 1H), 7.68 (ddd, J=7.8, 1.2, 1.2 Hz, 1H), 7.56 (dddd, J=7.8, 0.9, 0.9, 0.9 Hz, 1H), 7.26 (dd, J=10.5, 8.0 Hz, 1H), 3.78 (br s, 4H).

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