반응 #575470

반응 방정식

2,5-dihydroxybenzoic acid methyl ester

1-bromooctadecane

potassium carbonate

→

2-hydroxy-5-(octadecyloxy)benzoic acid methyl ester

수율 70.0%

용매

acetone

반응 조건

후처리

1. 1
   온도at reflux for 24 hours
2. 2
   기타The solvent was removed at reduced pressure
3. 3
   workup.ADDITIONthe residue was treated with water
4. 4
   추출The product was extracted with ethyl acetate
5. 5
   추출the dried extract
6. 6
   농축was concentrated to a solid which
7. 7
   기타was recrystallized from ethyl acetate-hexane

실험 절차

A mixture of 2.0 g (11.9 mmol) of 2,5-dihydroxybenzoic acid methyl ester, 4.55 g (13.1 mmol) of 1-bromooctadecane and 1.9 g (13.7 mmol) of potassium carbonate in 50 ml of acetone was stirred at reflux for 24 hours. The solvent was removed at reduced pressure and the residue was treated with water. The product was extracted with ethyl acetate and the dried extract was concentrated to a solid which was recrystallized from ethyl acetate-hexane to give 3.5 g (70% yield, mp 53°-54°) of 2-hydroxy-5-(octadecyloxy)benzoic acid methyl ester.

출처