반응 #57524

반응 방정식

(6-bromo-3-methyl-benzofuran-2-yl)-(2,4-dichloro-phenyl)-methanone

N-bromosuccinimide

2,2′-azobisisobutyronitrile

→

desired product

수율 78.9%

(6-bromo-3-bromomethyl-benzofuran-2-yl)-(2,4-dichloro-phenyl)-methanone

수율 78.9%

용매

carbon tetrachloride

반응 조건

후처리

1. 1
   온도The reaction mixture was refluxed for 6 h
2. 2
   여과filtered
3. 3
   농축The filtrate was concentrated
4. 4
   기타the crude product was triturated with 10% EtOAc/hexane

실험 절차

To a solution of (6-bromo-3-methyl-benzofuran-2-yl)-(2,4-dichloro-phenyl)-methanone (3.0 g, 7.81 mmol) in carbon tetrachloride (30 mL) was added N-bromosuccinimide (1.46 g, 8.2 mmol) and 2,2′-azobisisobutyronitrile (128 mg, 0.78 mmol). The reaction mixture was refluxed for 6 h, then filtered. The filtrate was concentrated and the crude product was triturated with 10% EtOAc/hexane to afford the desired product as a pale yellow solid (2.85 g, 78.9%). This material was used in the subsequent step without further purification.

출처