반응 #57519

반응 방정식

2-(2,4-Dichloro-benzoyl)-6-m-tolyl-benzofuran-3-carboxylic acid amide

SOCl2

→

solid

수율 13.2%

2,4-Dichloro-benzoyl-6-m-tolyl-benzofuran-3-carbonitrile

수율 13.2%

반응 조건

후처리

1. 1
   온도The reaction was cooled down to rt
2. 2
   기타the solvent was removed under reduced pressure
3. 3
   기타The residue was purified by pre-HPLC

실험 절차

A mixture of 2-(2,4-Dichloro-benzoyl)-6-m-tolyl-benzofuran-3-carboxylic acid amide from Example 2 step 7 (46.2 mg, 0.11 mmol) and SOCl2 (3 mL) was heated at 80° C. for 15 h. The reaction was cooled down to rt and the solvent was removed under reduced pressure. The residue was purified by pre-HPLC to afford a yellow solid (5.9 mg, 13%) as product. 1H-NMR (CDCl3): δ 7.88 (d, J=8.3 Hz, 1H), 7.79 (s, 1H), 7.73 (dd, J=1.5, 8.3 Hz, 1H), 7.54 (d, J=1.5 Hz, 1H), 7.52 (d, J=8.3 Hz, 1H), 7.4 (dd, J=1.5, 8.3 Hz, 1H), 7.41 (m, 2H), 7.36 (t, 1H), 7.23 (d, J=8.3 Hz, 1H), 2.42 (s, 3H); LC-MS (MH+=406/408).

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