반응 #57410

반응 방정식

α-Bromo-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid

ammonium hydroxide

ammonium hydroxide

→

a-amino-3-hydroxytricyclo[3.3.1.1 3,7]decane-1-acetic acid

반응 조건

후처리

1. 1
   농축The reaction mixture is then concentrated to a solid
2. 2
   workup.ADDITIONEtOH is then added
3. 3
   농축the reaction is again concentrated

실험 절차

α-Bromo-3-hydroxytricyclo[3.3.1.13,7]decane-1-acetic acid (Formula Q) is then dissolved in ammonium hydroxide, preferably 30% ammonium hydroxide and the reaction mixture is heated preferably to 65° C. The reaction mixture is then concentrated to a solid. EtOH is then added and the reaction is again concentrated to yield a racemic mixture comprising (<aS)-<a-amino-3-hydroxytricyclo[3.3.1.1 3,7]decane-1-acetic acid (Formula V). See also Example 19 herein.

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