반응 #57397

반응 방정식

N-(4-hydroxy-2,3,6-trimethylphenyl)formamide

potassium carbonate

dimethylformamide

1-(3-chloro-2-methyl-1-propenyl)-4-methylbenzene

→

title compound

수율 78.9%

N-[2,3,6-trimethyl-4-[[2-methyl-3-(4-methylphenyl)-2-propenyl]oxy]phenyl]formamide

수율 78.9%

용매

Water

toluene

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture was stirred at 30° C. for 1 hr
2. 2
   여과The precipitated crystals were collected by filtration
3. 3
   세척washed with water and isopropylether

실험 절차

To a mixture of N-(4-hydroxy-2,3,6-trimethylphenyl)formamide (660.4 g), potassium carbonate (1019 g) and dimethylformamide (3302 ml) was added a solution of 1-(3-chloro-2-methyl-1-propenyl)-4-methylbenzene (755 g) in toluene (675 ml), and the mixture was stirred at 50° C. for 14 hr. Water (5944 ml) was then added thereto and the mixture was stirred at 30° C. for 1 hr. The precipitated crystals were collected by filtration and washed with water and isopropylether to give the title compound (940 g, yield 74.5%).

출처