반응 #57304

반응 방정식

2-methoxyphenethylamine

thiophosgene

water

→

(2-methoxyphenethyl)isothiocyanate

수율 71.1%

용매

diethylether

반응 조건

후처리

1. 1
   추출The mixture was extracted with diethylether (60 ml)
2. 2
   건조dried over anhydrous magnesium sulfate
3. 3
   농축concentrated under reduced pressure

실험 절차

To a solution of 2-methoxyphenethylamine (1.98 g) in diethylether (20 ml) was added dropwise under ice-cooling thiophosgene (1.54 g). The mixture was stirred at room temperature for 1 hour. To the solution was added water (30 ml). The mixture was extracted with diethylether (60 ml), dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give (2-methoxyphenethyl)isothiocyanate (1.80 g, yield: 71%) as brown oil.

출처