반응 #572175

반응 방정식

Benzyl chloride

KOH

xylene

Water

→

3-benzyloxypropanol

용매

1,3-propanediol

반응 조건

후처리

1. 1
   추출the mixture was extracted twice with 600 ml of methylene chloride
2. 2
   세척The combined methylene chloride extracts were washed three times with 400 ml of water
3. 3
   건조dried over MgSO4
4. 4
   여과filtered
5. 5
   기타evaporated to a yellow oil which
6. 6
   workup.DISTILLATIONwas distilled under vacuum
7. 7
   기타The 98°-106° C. (1.5 mm) fraction was collected

실험 절차

Benzyl chloride (104 g, 1.0 m) was added dropwise to a solution of KOH (112 g, 2.0 m) in a mixture of 100 ml of xylene and 304 g of 1,3-propanediol at 50°-60° C. The solution was then heated at 100° C. for 2 hours. Water (400 ml) was added to the cooled solution and the mixture was extracted twice with 600 ml of methylene chloride. The combined methylene chloride extracts were washed three times with 400 ml of water, dried over MgSO4, filtered and evaporated to a yellow oil which was distilled under vacuum. The 98°-106° C. (1.5 mm) fraction was collected to give 88.7 g of 3-benzyloxypropanol.

출처