반응 #57216

반응 방정식

3-bromo-(4-nitrophenyl)-ethanone

thioacetamide

Ethyl acetate

→

title product

수율 80.0%

2-methyl-4-(4-nitrophenyl)-1,3-thiazole

수율 80.0%

용매

N,N-dimethylformamide

반응 조건

후처리

1. 1
   세척the solution was washed with water (3×20 mL)
2. 2
   기타The product was purified by crystallization from ether

실험 절차

A solution of 3-bromo-(4-nitrophenyl)-ethanone (2.5 mmol) and thioacetamide (3 mmol) in N,N-dimethylformamide (20 mL) was heated at 65° C. for 8 h. Ethyl acetate (40 mL) was added and the solution was washed with water (3×20 mL). The product was purified by crystallization from ether to give the title product (80%). ESMS [M+H]+: 221.2

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