반응 #5720

반응 방정식

methyl acetoacetate

ethyl bromide

sodium methylate

→

methyl 2-acetylbutyrate

수율 56.9%

용매

methanol

반응 조건

후처리

1. 1
   온도at reflux
2. 2
   workup.DISTILLATIONAfter distillation of the methanol the residue
3. 3
   workup.ADDITIONwas poured on to ice-water
4. 4
   추출It was then extracted with n-hexane and water
5. 5
   기타dried
6. 6
   기타After evaporation of the solvent
7. 7
   workup.DISTILLATIONdistillation there

실험 절차

465 g of methyl acetoacetate and then 458 g of ethyl bromide were added under nitrogen to 720 g of 30% sodium methylate solution in 1200 ml of methanol. The reaction mixture was subsequently boiled at reflux. After distillation of the methanol the residue was poured on to ice-water. It was then extracted with n-hexane and water. The organic phases were combined and dried. After evaporation of the solvent and distillation there were obtained 328 g (56.9%) of methyl 2-acetylbutyrate, b.p. 77°-79°/15 Torr.

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