반응 #57135

반응 방정식

water

{4-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}methylamine

triethylamine

phenyl isocyanate

tetrahydrofuran

→

title product

수율 42.0%

N-{4-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}-N-methyl-N′-phenylurea

수율 42.0%

반응 조건

후처리

1. 1
   추출extracted with (3×1 mL) ethyl acetate
2. 2
   세척The combined organic layers were washed with water (2×1 mL), brine (1×1 mL)
3. 3
   건조dried over sodium sulfate
4. 4
   농축concentrated in vacuo
5. 5
   기타Purification of the residue by Gilson reverse phase HPLC

실험 절차

A solution of {4-[1-ethyl-4-(1H-pyrrolo[2,3-b]pyridin-4-yl)-1H-pyrazol-3-yl]phenyl}methylamine (0.16 mmol) in tetrahydrofuran (1 mL) was treated with triethylamine (0.17 mmol), and phenyl isocyanate (0.17 mmol). After stirring 18 h at room temperature the reaction was poured into water (1 mL), and extracted with (3×1 mL) ethyl acetate. The combined organic layers were washed with water (2×1 mL), brine (1×1 mL) dried over sodium sulfate and concentrated in vacuo. Purification of the residue by Gilson reverse phase HPLC provided the title product as a white powder (42%). ESMS [M+H]+: 437.2

출처