반응 #571240

반응 방정식

4-aminomethylpiperidine

potassium carbonate

1-methyl-2-chlorobenzimidazole

→

1-(1-METHYLBENZIMIDAZOL-2-YL)-4-AMINOMETHYLPIPERIDINE

용매

toluene

반응 조건

후처리

1. 1
   온도to reflux for 48 hours
2. 2
   기타After evaporation
3. 3
   기타The precipitate formed
4. 4
   세척washed with ether
5. 5
   workup.ADDITION30% caustic soda is added
6. 6
   기타to give a basic pH

실험 절차

27 g of 4-aminomethylpiperidine are placed in 300 ml of anhydrous toluene in the presence of 33 g of potassium carbonate and of 33 g of 1-methyl-2-chlorobenzimidazole. The mixture is subjected to reflux for 48 hours. After evaporation, the residue is taken up in ether and an excess of hydrochloric ether. The precipitate formed is spun down, washed with ether, and then taken up in 750 ml of water and 30% caustic soda is added to give a basic pH.

출처