반응 #570801

반응 방정식

5-(1,3-dioxolan-2-yl)-2,3-pyridinedicarboxylic anhydride

2-amino-2,3-dimethylbutyramide

→

title compound

수율 128.1%

2-[(1-Carbamoyl-1,2-dimethylpropyl)-carbamoyl]-5-(1,3-dioxolan-2-yl)nicotinic acid

수율 128.1%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   농축The reaction mixture is concentrated in vacuo

실험 절차

A solution of 5-(1,3-dioxolan-2-yl)-2,3-pyridinedicarboxylic anhydride (2.64 g, 0.012 mol) and 2-amino-2,3-dimethylbutyramide (1.55 g, 0.012 mol) in tetrahydrofuran is stirred for 2 days at room temperature. The reaction mixture is concentrated in vacuo to give the title compound as an orange oil (5.4 g, 100%), identified by NMR spectra analysis.

출처