반응 #57066

반응 방정식

MeOH

water

furan

BuLi

PhMe

→

25

수율 54.0%

5,8-epoxy-5,8-dihydronaphtho[2,3-d][1,3]dioxole

수율 54.0%

반응 조건

후처리

1. 1
   온도to warm to rt
2. 2
   workup.WAITAfter 3 hours
3. 3
   기타The organic layer was separated
4. 4
   추출the aqueous layer was extracted three times with Et2O
5. 5
   세척The combined organic layers were washed with brine
6. 6
   건조dried over MgSO4
7. 7
   농축concentrated
8. 8
   기타Recrystallization from hexanes

실험 절차

To 3,4-dibromobenzo-1,3-dioxolane (1.54 g, 5.50 mmol) and furan (4 g, 58.8 mmol) in PhMe (55 mL) at −78° C. was added BuLi (2.2 mL, 2.5M in hexanes, 5.5 mmol) dropwise. The reaction was stirred for two hours at −78° C. and the allowed to warm to rt. After 3 hours, MeOH (2 mL) was added and the reaction mixture was poured into water. The organic layer was separated and the aqueous layer was extracted three times with Et2O. The combined organic layers were washed with brine, dried over MgSO4, and concentrated. Recrystallization from hexanes gave 25 (560 mg, 54%) as white crystals). Rf=0.47 on silica gel (30% ethyl acetate:hexanes); mp 111-112° C. (Et2O); IR (KBr, cm−1) 2895, 1455, 1292, 1138, 1038, 1014, 848; 1H NMR (400 MHz, CDCl3) δ 7.02 (2H, dd, J=0.9, 0.9 Hz), 6.82 (2H, s), 5.92 (1H, d, J=1.5 Hz), 5.87 (1H, d, J=1.5 Hz), 5.62 (2H, s); 13C NMR (400 MHz, CDCl3) δ 144.3, 143.3, 103.9, 101.1, 82.4. HRMS calcd for C11H02 (M+): 188.0473. Found: 188.0463.

출처