반응 #570349

반응 방정식

3-acetoxymethylcarbostyril

methanol

water

→

3-hydroxymethyl-6-methoxycarbostyril

용매

sodium hydroxide

반응 조건

후처리

1. 1
   온도the mixture was refluxed for 3 hours
2. 2
   기타After removal of methanol
3. 3
   workup.DISTILLATIONby distillation
4. 4
   기타to the residue thus obtained
5. 5
   기타the crystals precipitated
6. 6
   여과were collected by filtration
7. 7
   기타Recrystallized from acetone

실험 절차

2 Grams of 3-acetoxymethylcarbostyril was dissolved in 30 ml of methanol containing 0.6 g of sodium hydroxide, then the mixture was refluxed for 3 hours. After removal of methanol by distillation, to the residue thus obtained was added water and the crystals precipitated were collected by filtration. Recrystallized from acetone to obtain 1.3 g of 3-hydroxymethyl-6-methoxycarbostyril in the form of light yellowish needle-like crystals.

출처