반응 #570338

반응 방정식

methyl 3-(4-carboxy-2nitrophenyl)propionate

sodium hydroxide methanol

→

7-carboxy-3,4-dihydrocarbostyril

용매

methanol

반응 조건

후처리

1. 1
   기타Then the catalyst was removed from the reaction mixture by filtration
2. 2
   workup.ADDITIONby adding concentrated hydrochloric acid
3. 3
   여과The precipitated crystals were collected by filtration
4. 4
   기타recrystallized from methanol

실험 절차

5 Grams of methyl 3-(4-carboxy-2nitrophenyl)propionate, 8.87 ml of 2.226N-sodium hydroxide methanol solution, 100 ml of methanol and 1 g of 5%-Pd-C (50% in water) were well mixed together and this mixture was catalytically reduced at a normal temperature under a normal pressure. Then the catalyst was removed from the reaction mixture by filtration, and the pH of the filtrate was adjusted to about pH=1 by adding concentrated hydrochloric acid. The precipitated crystals were collected by filtration and recrystallized from methanol to obtain 3.62 g of 7-carboxy-3,4-dihydrocarbostyril in the form of colorless needle-like crystals.

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