반응 #570149

반응 방정식

aminoguanidine bicarbonate

2-acetyl butyrolactone

→

desired intermediate

수율 65.2%

2,3-Diamino-5-(2-hydroxyethyl)-6-methyl-4(3H)-pyrimidinone

수율 65.2%

용매

n-butanol

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux until a clear solution
3. 3
   기타was obtained
4. 4
   온도This solution was cooled
5. 5
   기타evaporated to dryness in vacuo
6. 6
   기타the residue was triturated with 200 ml of a 50/50 ether-chloroform mixture

실험 절차

A mixture of 13.6 g of aminoguanidine bicarbonate and 12.8 g of 2-acetyl butyrolactone in 80 ml of n-butanol was heated at reflux until a clear solution was obtained. This solution was cooled, evaporated to dryness in vacuo and the residue was triturated with 200 ml of a 50/50 ether-chloroform mixture, giving 12 g of the desired intermediate, mp 126°-135° C.

출처