반응 #56934

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6-[5-bromo-2-(4-nitro-benzyloxy)-phenyl]-6-chloro-pyrimidin-2-ylamine

4-chloro-phenylamine

→

title compound

수율 82.0%

6-[5-Bromo-2-(4-nitro-benzyloxy)-phenyl]-N*4*-(4-chloro-phenyl)-pyrimidine-2,4-diamine

수율 82.0%

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실험 절차

Following the method described in Example 4, 6-[5-bromo-2-(4-nitro-benzyloxy)-phenyl]-6-chloro-pyrimidin-2-ylamine and 4-chloro-phenylamine provided the title compound (82% yield) as its hydrochloride salt. 1H NMR (DMSO-d6) δ 5.42 (s, 2H, CH2), 6.55 (s, 1H, Ar), 7.29 (d, 1H, J=9.4 Hz, Ar), 7.45 (d, 2H, J=8.8 Hz, Ar), 7.72-7.84 (m, 6H, Ar), 8.24 (d, 2H, J=8.7 Hz, Ar).

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